Type

Journal Article

Authors

Daniel J Kelly
Caitríona Lally
Niamh Hynes
Sherif Sultan
Arthur Creane
Eoghan Maher

Subjects

Pharmacology

Topics
computer simulation hardness fresh tensile properties male atherosclerotic plaques compressive strength mechanical manufacturing engineering aged next generation medical devices stress mechanical physiopathology humans models cardiovascular tensile strength elastic modulus carotid arteries carotid stenosis female human

Tensile and compressive properties of fresh human carotid atherosclerotic plaques. (2009)

Abstract Accurate characterisation of the mechanical properties of human atherosclerotic plaque is important for our understanding of the role of vascular mechanics in the development and treatment of atherosclerosis. The majority of previous studies investigating the mechanical properties of human plaque are based on tests of plaque tissue removed following autopsy. This study aims to characterise the mechanical behaviour of fresh human carotid plaques removed during endarterectomy and tested within 2h. A total of 50 radial compressive and 17 circumferential tensile uniaxial tests were performed on samples taken from 14 carotid plaques. The clinical classification of each plaque, as determined by duplex ultrasound is also reported. Plaques were classified as calcified, mixed or echolucent. Experimental data indicated that plaques were highly inhomogeneous; with variations seen in the mechanical properties of plaque obtained from individual donors and between donors. The mean behaviour of samples for each classification indicated that calcified plaques had the stiffest response, while echolucent plaques were the least stiff. Results also indicated that there may be a difference in behaviour of samples taken from different anatomical locations (common, internal and external carotid), however the large variability indicates that more testing is needed to reach significant conclusions. This work represents a step towards a better understanding of the in vivo mechanical behaviour of human atherosclerotic plaque.
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Full list of authors on original publication

Daniel J Kelly, Caitríona Lally, Niamh Hynes, Sherif Sultan, Arthur Creane, Eoghan Maher

Experts in our system

1
Daniel Kelly
Trinity College Dublin
Total Publications: 168
 
2
Caitríona Lally
Dublin City University
Total Publications: 33