Type

Journal Article

Authors

Aiden Corvin
Derek W Morris
Michael Gill
Ricardo Segurado
Elizabeth A Heron
Elaine Kenny
Colm O'Dushlaine

Subjects

Microbiology

Topics
genome databases genetic genome wide association study computational biology parkinson disease polymorphism single nucleotide genetics humans

The SNP ratio test: pathway analysis of genome-wide association datasets. (2009)

Abstract We present a tool that assesses the enrichment of significant associations from genome-wide association studies (GWAS) in a pathway context. The SNP ratio test (SRT) compares the proportion of significant to all SNPs within genes that are part of a pathway and computes an empirical P-value based on comparisons to ratios in datasets where the assignment of case/control status has been randomized. We applied the SRT to a Parkinson's disease GWAS dataset, using the KEGG database, revealing significance for Parkinson's disease and related pathways. AVAILABILITY: https://sourceforge.net/projects/snpratiotest/
Collections Ireland -> Trinity College Dublin -> PubMed

Full list of authors on original publication

Aiden Corvin, Derek W Morris, Michael Gill, Ricardo Segurado, Elizabeth A Heron, Elaine Kenny, Colm O'Dushlaine

Experts in our system

1
Aiden Corvin
Trinity College Dublin
Total Publications: 190
 
2
Derek Morris
Trinity College Dublin
Total Publications: 150
 
3
Michael Gill
Trinity College Dublin
Total Publications: 260
 
4
Ricardo Segurado
University College Dublin
Total Publications: 58
 
5
Elizabeth Heron
Trinity College Dublin
Total Publications: 14
 
6
Elaine Kenny
Trinity College Dublin
Total Publications: 28
 
7
Colm T O'Dushlaine
Trinity College Dublin
Total Publications: 28