Journal Article


R A Kenny
B A Lawlor
Sean P Kennelly


Medicine & Nursing

complications humans risk factors physiology hypotension hypertension aging etiology blood pressure dementia

Blood pressure and the risk for dementia: a double edged sword. (2008)

Abstract Alzheimer's disease (AD) and vascular dementia (VaD) are important causes of cognitive decline in the elderly. As a result of the aging population, the incidence of dementia is expected to increase substantially over the coming decades. Many studies have identified that vascular risk factors are implicated in the pathogenesis of both AD and VaD. Longitudinal studies have suggested that high blood pressure in midlife is associated with a higher incidence of both AD and VaD in later life. The association appears weaker for hypertension in later life. Some studies also suggest that hypotension; especially low diastolic blood pressure in late-life is also associated with an increased risk of AD. Long-standing hypertension may lead to severe atherosclerosis and impaired cerebrovascular autoregulation. A decline in blood pressure in later life may contribute to diminished cerebral perfusion. The subsequent ischaemic state may lead to increased cerebral beta-amyloid accumulation.
Collections Ireland -> Trinity College Dublin -> PubMed

Full list of authors on original publication

R A Kenny, B A Lawlor, Sean P Kennelly

Experts in our system

Rose Anne Kenny
Trinity College Dublin
Total Publications: 252
Brian A. Lawlor
National College Ireland
Total Publications: 125
Sean P Kennelly
TU Dublin (Tallaght Campus)
Total Publications: 47