Type

Journal Article

Authors

Mark A. Bellgrove
Michael Gill
Ziarih Hawi
Thomas J Connor
Caroline McDonnell
David Lambert
Michael Daly
Aisling Mulligan
Edwina Barry
Ian H Robertson
and 2 others

Subjects

Psychiatry

Topics
polymorphism genetic child receptors dopamine d4 children controls attention humans attention deficit disorder with hyperactivity genotype adolescent minisatellite repeats case control studies psychology sustained attention genetic linkage genetics drd4 protein human gene frequency task performance and analysis adhd intelligence tests genetic predisposition to disease variant physiology physiopathology

Absence of the 7-repeat variant of the DRD4 VNTR is associated with drifting sustained attention in children with ADHD but not in controls. (2008)

Abstract Many genetic studies have demonstrated an association between the 7-repeat (7r) allele of a 48-base pair variable number of tandem repeats (VNTR) in exon 3 of the DRD4 gene and the phenotype of attention deficit hyperactivity disorder (ADHD). Previous studies have shown inconsistent associations between the 7r allele and neurocognitive performance in children with ADHD. We investigated the performance of 128 children with and without ADHD on the Fixed and Random versions of the Sustained Attention to Response Task (SART). We employed time-series analyses of reaction-time data to allow a fine-grained analysis of reaction time variability, a candidate endophenotype for ADHD. Children were grouped into either the 7r-present group (possessing at least one copy of the 7r allele) or the 7r-absent group. The ADHD group made significantly more commission errors and was significantly more variable in RT in terms of fast moment-to-moment variability than the control group, but no effect of genotype was found on these measures. Children with ADHD without the 7r allele made significantly more omission errors, were significantly more variable in the slow frequency domain and showed less sensitivity to the signal (d') than those children with ADHD the 7r and control children with or without the 7r. These results highlight the utility of time-series analyses of reaction time data for delineating the neuropsychological deficits associated with ADHD and the DRD4 VNTR. Absence of the 7-repeat allele in children with ADHD is associated with a neurocognitive profile of drifting sustained attention that gives rise to variable and inconsistent performance.
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Full list of authors on original publication

Mark A. Bellgrove, Michael Gill, Ziarih Hawi, Thomas J Connor, Caroline McDonnell, David Lambert, Michael Daly, Aisling Mulligan, Edwina Barry, Ian H Robertson and 2 others

Experts in our system

1
Mark A. Bellgrove
Trinity College Dublin
Total Publications: 35
 
2
Michael Gill
Trinity College Dublin
Total Publications: 260
 
3
Ziarih Hawi
Trinity College Dublin
Total Publications: 28
 
4
Thomas Joseph Connor
Trinity College Dublin
Total Publications: 13
 
5
Michael Daly
University College Dublin
 
6
Aisling Mulligan
Trinity College Dublin
Total Publications: 10
 
7
Ian H Robertson
Trinity College Dublin
Total Publications: 142