Journal Article


Michael Gill
Stephen V Faraone
Philip Asherson
Margaret Thompson
Eric Taylor
Hans-Christoph Steinhausen
Joseph Sergeant
Aribert Rothenberger
Nanda Rommelse
Herbert Roeyers
and 18 others



polymorphism single nucleotide linkage disequilibrium humans risk factors family parents alleles chi square distribution genetic predisposition to disease genetics attention deficit disorder with hyperactivity genetic markers data interpretation statistical etiology

Parent of origin effects in attention/deficit hyperactivity disorder (ADHD): analysis of data from the international multicenter ADHD genetics (IMAGE) program. (2008)

Abstract There are conflicting reports suggesting that the parental origin of transmitted risk alleles may play a role in the etiology of attention deficit/hyperactivity disorder (ADHD). A recent report by Hawi and colleagues observed a generalized paternal over-transmission of alleles associated with ADHD. This was not replicated in more recent studies. Using data from a large multicenter study we examined the overall and gene-specific parent of origin effect in 554 independent SNPs across 47 genes. Transmission disequilibrium and explicit parent of origin test were performed using PLINK. Overall parent of origin effect was tested by Chi-square. There was no overall parent of origin effect in the IMAGE sample (chi(1)(2) = 1.82, P = 0.117). Five markers in three genes, DDC, TPH2, and SLC6A2 showed nominal association (P < 0.01) with ADHD combined subtype when restricted to maternal or paternal transmission only. Following the initial report by Hawi and co-workers three studies, including this one, found no evidence to support an overall parent of origin effect for markers associated with ADHD. We cannot however, exclude gene-specific parent of origin effect in the etiology ADHD.
Collections Ireland -> Trinity College Dublin -> PubMed

Full list of authors on original publication

Michael Gill, Stephen V Faraone, Philip Asherson, Margaret Thompson, Eric Taylor, Hans-Christoph Steinhausen, Joseph Sergeant, Aribert Rothenberger, Nanda Rommelse, Herbert Roeyers and 18 others

Experts in our system

Michael Gill
Trinity College Dublin
Total Publications: 294
Philip Asherson
University College Dublin
Total Publications: 9