Type

Journal Article

Authors

Michael Gill
Derek Morris
Siobhan Schwaiger
Jeanne Marie Nangle
Gary Donohoe
Aiden Corvin

Subjects

Psychiatry

Topics
polymorphism single nucleotide bipolar disorder middle aged adult analysis of variance humans gene frequency schizophrenia carrier proteins female psychiatric status rating scales genetics genetic predisposition to disease complications principal component analysis haplotypes male etiology dtnbp1 protein human

A dysbindin risk haplotype associated with less severe manic-type symptoms in psychosis. (2007)

Abstract Delineating relationships between susceptibility genes and clinical symptoms may be an important step in understanding the genetics of psychosis. Recent data suggests that the gene dysbindin (DTNBP1) may confer susceptibility across psychotic disorders and may particularly be associated with negative symptoms, i.e. affective flattening, alogia and avolition. We have previously published evidence of association with a dysbindin risk haplotype derived from alleles C-A-T at SNPs P1655 (rs2619539), P1635 (rs3213207) and SNP66961 (rs2619538) in two independent schizophrenia (SZ) case-control samples. The C-A-T haplotype impacts at the level of gene function and phenotype: the haplotype indexes lower cortical expression of the dysbindin gene in post-mortem SZ brain samples and haplotype carriers show greater deficits in spatial working memory and early visual processing than non-carrier SZ patients. The aim of this study was to establish if the C-A-T dysbindin risk haplotype is associated with a specific clinical symptom profile. We investigated the relationship between the haplotype and PANSS-derived symptom factors in 262 individuals with schizophrenia/schizoaffective disorder using principal components analysis (PCA) and analysis of variance (ANOVA). Dysbindin risk carriers scored significantly less than non-carriers on the 'hostility/excitability' factor (F 1,196=8.468; p=.004), with a trend for higher negative symptom scores. This suggests that risk variation at the dysbindin gene may contribute to a more prototypical SZ presentation with less severe excitement/manic symptoms and more negative symptoms.
Collections Ireland -> Trinity College Dublin -> PubMed

Full list of authors on original publication

Michael Gill, Derek Morris, Siobhan Schwaiger, Jeanne Marie Nangle, Gary Donohoe, Aiden Corvin

Experts in our system

1
Michael Gill
Trinity College Dublin
Total Publications: 260
 
2
Derek Morris
Trinity College Dublin
Total Publications: 150
 
3
Gary Donohoe
Trinity College Dublin
Total Publications: 130
 
4
Aiden Corvin
Trinity College Dublin
Total Publications: 190