Journal Article


John J Foxe
Aiden P Corvin
Michael Gill
Daniel C Javitt
Ian H Robertson
Hugh P Garavan
Jennifer L Montesi
Elena Magno
Pierfilippo De Sanctis
Derek W Morris
and 1 others



frontal lobe evoked potentials visual middle aged higher nervous activity physiology schizophrenic psychology phenotype schizophrenia electroencephalography haplotypes signal processing computer assisted agnosia dtnbp1 protein human adult pattern recognition visual humans reaction time gene expression adolescent carrier proteins physiopathology occipital lobe female genetics heterozygote detection psychology schizotypal personality disorder diagnosis parietal lobe genetic predisposition to disease male

Early visual processing deficits in dysbindin-associated schizophrenia. (2007)

Abstract Variation at the dysbindin gene (DTNBP1) has been associated with increased risk for schizophrenia in numerous independent samples and recently with deficits in general and domain-specific cognitive processing. The relationship between dysbindin risk variants and sensory-level deficits in schizophrenia remains to be explored. We investigated P1 performance, a component of early visual processing on which both patients and their relatives show deficits, in carriers and noncarriers of a known dysbindin risk haplotype. Event-related potential responses to simple visual isolated-check stimuli were measured using high-density electrical scalp recordings in 26 individuals meeting DSM-IV criteria for schizophrenia, comprising 14 patients who were carriers of the dysbindin risk haplotype and 12 patients who were nonrisk haplotype carriers. Carriers of the dysbindin risk haplotype demonstrated significantly reduced P1 amplitudes compared with noncarriers. A large effect size of d = .89 was calculated for the difference in P1 amplitude over scalp sites where the deficit was maximal. The P1 deficits associated with a dysbindin risk haplotype previously identified in our sample presents functional confirmation of its deleterious effect on brain activity. Building on evidence of dysbindin's role in higher cognitive function, these early visual processing deficits suggest a generalized role for dysbindin in brain function and is likely to be part of the mechanism by which illness susceptibility is mediated.
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Full list of authors on original publication

John J Foxe, Aiden P Corvin, Michael Gill, Daniel C Javitt, Ian H Robertson, Hugh P Garavan, Jennifer L Montesi, Elena Magno, Pierfilippo De Sanctis, Derek W Morris and 1 others

Experts in our system

John J Foxe
Trinity College Dublin
Total Publications: 44
Aiden Corvin
Trinity College Dublin
Total Publications: 218
Michael Gill
Trinity College Dublin
Total Publications: 294
Ian H Robertson
Trinity College Dublin
Total Publications: 162
Hugh Garavan
Trinity College Dublin
Total Publications: 170
Pierfilippo De Sanctis
Dublin Institute of Technology
Derek Morris
Trinity College Dublin
Total Publications: 168