Type

Journal Article

Authors

Michael Gill
Derek Morris
Jeanne Marie Nangle
Siobhan Schwaiger
Niamh Kenny
Kevin Murphy
Kevin McGhee
Gary Donohoe
Aiden Corvin

Subjects

Psychiatry

Topics
mood disorders female etiology principal component analysis complications genotype genetics genetic predisposition to disease d amino acid oxidase male polymorphism single nucleotide middle aged adult humans schizophrenic psychology brief psychiatric rating scale chi square distribution gene frequency schizophrenia

D-amino acid oxidase (DAO) genotype and mood symptomatology in schizophrenia. (2007)

Abstract A series of genetic studies have identified the D-amino acid oxidase (DAO) gene as potentially contributing to schizophrenia susceptibility. An interacting gene, D-amino acid oxidase activator (DAOA) has also been implicated and it has been suggested that variation at these genes may influence the efficiency of glutamate gating at N-methyl-D-aspartate-type (NMDA) receptors. However, recent data suggests that DAOA may influence susceptibility to mood episodes across the spectrum of psychotic disorders rather than contributing to a specific psychosis phenotype. The aim of this study was to determine whether risk variation at DAO is similarly associated with affective or other clinical symptoms in psychosis. We have previously reported association between risk variation at DAO and schizophrenia in an Irish case-control sample. In this study we investigated the relationship between a defined genetic risk variant at DAO and PANSS-derived clinical symptom factors in a sample of 249 patients using principal component and Kruskal-Wallis analyses. Carriers of the DAO risk variant scored significantly higher on the 'depression/anxiety' factor than non-carriers (H=9.02, d.f.=2, p=0.01). These data suggest a potential role for DAO in susceptibility to depressive symptoms in schizophrenia, but a more general role for DAO in affective disorders cannot be excluded.
Collections Ireland -> Trinity College Dublin -> PubMed

Full list of authors on original publication

Michael Gill, Derek Morris, Jeanne Marie Nangle, Siobhan Schwaiger, Niamh Kenny, Kevin Murphy, Kevin McGhee, Gary Donohoe, Aiden Corvin

Experts in our system

1
Michael Gill
Trinity College Dublin
Total Publications: 260
 
2
Derek Morris
Trinity College Dublin
Total Publications: 150
 
3
Gary Donohoe
Trinity College Dublin
Total Publications: 130
 
4
Aiden Corvin
Trinity College Dublin
Total Publications: 190