Type

Journal Article

Authors

Marek W Radomski
Paul Jurasz
Carlos Medina
Maria Jose Santos-Martinez

Subjects

Biochemistry

Topics
physiology vascular diseases humans tumor necrosis factor alpha convertase platelet aggregation adamts13 protein human animals blood platelets etiology adam proteins metalloproteases inflammation

Role of metalloproteinases in platelet function. (2007)

Abstract Platelets contain and release matrix metalloproteinases (MMPs), their inhibitors (TIMPs) and disintegrin metalloproteinases (ADAMs) including MMP-1, MMP-2, MMP-3, MMP-9, MT1-MMP (MMP-14), ADAM-10, ADAM-17, ADAMTS-13, TIMP-1, TIMP-2 and TIMP-4. These proteins exert several effects regulating platelet functions such as agonist-stimulated platelet adhesion and aggregation, tumour cell-induced platelet aggregation and platelet-leukocyte aggregation. In this review, mechanisms of MMPs, TIMPs and ADAMs on platelets are discussed.
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Full list of authors on original publication

Marek W Radomski, Paul Jurasz, Carlos Medina, Maria Jose Santos-Martinez

Experts in our system

1
Marek W Radomski
Trinity College Dublin
Total Publications: 44
 
2
Carlos Medina
Trinity College Dublin
Total Publications: 23
 
3
Maria Jose Santos-Martinez
Trinity College Dublin
Total Publications: 29