Type

Journal Article

Authors

Mark A. Bellgrove
Michael Gill
Louise Gallagher
Michael Fitzgerald
Michelle Keavey
Amy Watchorn
Aoife Daibhis
Edwina Barry
Timothy J Silk
Simon P Kelly
and 2 others

Subjects

Psychiatry

Topics
attention neuropsychological tests physiology spectrum analysis task performance and analysis humans adolescent statistics numerical data child reaction time linear models choice behavior inhibition psychology dissociative disorders attention deficit disorder with hyperactivity photic stimulation animals physiopathology autistic disorder male etiology

Dissociation in performance of children with ADHD and high-functioning autism on a task of sustained attention. (2006)

Abstract Attention deficit hyperactivity disorder (ADHD) and autism are two neurodevelopmental disorders associated with prominent executive dysfunction, which may be underpinned by disruption within fronto-striatal and fronto-parietal circuits. We probed executive function in these disorders using a sustained attention task with a validated brain-behaviour basis. Twenty-three children with ADHD, 21 children with high-functioning autism (HFA) and 18 control children were tested on the Sustained Attention to Response Task (SART). In a fixed sequence version of the task, children were required to withhold their response to a predictably occurring no-go target (3) in a 1-9 digit sequence; in the random version the sequence was unpredictable. The ADHD group showed clear deficits in response inhibition and sustained attention, through higher errors of commission and omission on both SART versions. The HFA group showed no sustained attention deficits, through a normal number of omission errors on both SART versions. The HFA group showed dissociation in response inhibition performance, as indexed by commission errors. On the Fixed SART, a normal number of errors was made, however when the stimuli were randomised, the HFA group made as many commission errors as the ADHD group. Greater slow-frequency variability in response time and a slowing in mean response time by the ADHD group suggested impaired arousal processes. The ADHD group showed greater fast-frequency variability in response time, indicative of impaired top-down control, relative to the HFA and control groups. These data imply involvement of fronto-parietal attentional networks and sub-cortical arousal systems in the pathology of ADHD and prefrontal cortex dysfunction in children with HFA.
Collections Ireland -> Trinity College Dublin -> PubMed

Full list of authors on original publication

Mark A. Bellgrove, Michael Gill, Louise Gallagher, Michael Fitzgerald, Michelle Keavey, Amy Watchorn, Aoife Daibhis, Edwina Barry, Timothy J Silk, Simon P Kelly and 2 others

Experts in our system

1
Mark A. Bellgrove
Trinity College Dublin
Total Publications: 35
 
2
Michael Gill
Trinity College Dublin
Total Publications: 260
 
3
Louise Gallagher
Trinity College Dublin
Total Publications: 55
 
4
Michael Fitzgerald
Trinity College Dublin
Total Publications: 90
 
5
Simon P Kelly
Trinity College Dublin
Total Publications: 42