Journal Article


David J Lynn
Daniel G Bradley
Fernando Cruz



evolution molecular genetics antigens cd3 phylogeny codon selection genetic oncorhynchus mykiss molecular sequence data amino acid sequence animals sequence homology amino acid salmo salar

Evidence of positive selection on the Atlantic salmon CD3gammadelta gene. (2006)

Abstract Atlantic salmon are typically anadromous, spending the majority of their lifetime in oceans and returning to fresh water to breed. This diversity of environments likely results in strong selective forces shaping their genome. In this paper, we present the first genomics approach to detect positive selection operating on the Salmo salar (salmon) lineage, an important aquaculture species. We identify a panel of candidate genes that may have been subject to adaptive evolution in this species. In particular, we identify a robust signature of positive selection operating on the salmon CD3gammadelta gene, which encodes one of the protein chains essential for formation of the T-cell receptor complex and for T-cell activation. Furthermore, we identified the particular codon sites that have been subject to positive selection in fish and highlight two sites flanking an important N-glycosylation site in this molecule.
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Full list of authors on original publication

David J Lynn, Daniel G Bradley, Fernando Cruz

Experts in our system

David J Lynn
Total Publications: 37
Daniel Bradley
Trinity College Dublin
Total Publications: 84