Type

Journal Article

Authors

Aiden Corvin
Michael Gill
Ian H Robertson
Hugh Garavan
Jeanne Marie Nangle
Siobhan Schwaiger
Kevin A McGhee
Sarah Clarke
Derek W Morris
Gary Donohoe

Subjects

Psychiatry

Topics
physiology haplotypes psychomotor performance humans middle aged schizophrenia adolescent attention dtnbp1 protein human cognition wechsler scales female genotype genetics schizophrenic psychology carrier proteins psychiatric status rating scales male adult memory short term heterozygote

Variance in neurocognitive performance is associated with dysbindin-1 in schizophrenia: a preliminary study. (2006)

Abstract Susceptibility genes for schizophrenia have been hypothesised to mediate liability for the disorder at least partly by influencing cognitive performance. We investigated the association between genotype and cognitive performance for a Dysbindin risk haplotype which is associated with schizophrenia in our sample. Fifty-two patients with schizophrenia or schizoaffective disorder (24 risk haplotypes carriers versus 28 non-risk haplotype carriers) were assessed in areas of cognition showing evidence of familial deficits in schizophrenia. Verbal and spatial memory, working memory, and attentional control was assessed using selected measures from the Weschler memory scale (WMS), Cambridge automated test battery (CANTAB), continuous performance test (CPT), and a simple go/no-go task. Pre-morbid IQ was also assessed using the Weschler Test of Adult Reading (WTAR). Patients carrying the Dysbindin risk haplotype showed significantly lower spatial working memory performance than patients who were non-risk carriers, with genotype explaining 12% of variance in performance. Our study suggests that the increased risk for schizophrenia associated with dysbindin may be partly mediated by its influence on pre-frontal function.
Collections Ireland -> Trinity College Dublin -> PubMed

Full list of authors on original publication

Aiden Corvin, Michael Gill, Ian H Robertson, Hugh Garavan, Jeanne Marie Nangle, Siobhan Schwaiger, Kevin A McGhee, Sarah Clarke, Derek W Morris, Gary Donohoe

Experts in our system

1
Aiden Corvin
Trinity College Dublin
Total Publications: 190
 
2
Michael Gill
Trinity College Dublin
Total Publications: 260
 
3
Ian H Robertson
Trinity College Dublin
Total Publications: 142
 
4
Hugh Garavan
Trinity College Dublin
Total Publications: 160
 
5
Derek Morris
Trinity College Dublin
Total Publications: 150
 
6
Gary Donohoe
Trinity College Dublin
Total Publications: 130