Journal Article


Clare Kelly
Catherine Fassbender
Kevin Murphy
Robert Hester
Hugh Garavan


Medicine & Nursing

adult blood supply physiology humans middle aged adolescent brain mapping analysis of variance magnetic resonance imaging anatomy histology female individuality time factors inhibition psychology photic stimulation electroencephalography image processing computer assisted oxygen brain evoked potentials blood

Individual differences in the functional neuroanatomy of inhibitory control. (2005)

Abstract We combined the data of five event-related fMRI studies of response inhibition. The re-analysis (n = 71) revealed response inhibition to be accomplished by a largely right hemisphere network of prefrontal, parietal, subcortical and midline regions, with converging evidence pointing to the particular importance of the right frontal operculum. Functional differences were observed between the sexes with greater activity in females in many of these cortical regions. Despite the relatively narrow age range (18-46), cortical activity, on the whole, tended to increase with age, echoing a pattern of functional recruitment often observed in the elderly. More absent minded subjects showed greater activity in fronto-parietal areas, while speed of Go trial responses produced a varied pattern of activation differences in more posterior and subcortical areas. Although response inhibition produces robust activation in a discrete network of brain regions, these results reveal that individual differences impact on the relative contribution made by the nodes of this network.
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Full list of authors on original publication

Clare Kelly, Catherine Fassbender, Kevin Murphy, Robert Hester, Hugh Garavan

Experts in our system

Clare Kelly
Trinity College Dublin
Total Publications: 7
Robert Hester
Trinity College Dublin
Total Publications: 14
Hugh Garavan
Trinity College Dublin
Total Publications: 160