Type

Journal Article

Authors

Katherine A Fitzgerald
Caroline A Jefferies

Subjects

Microbiology

Topics
gene expression regulation toll like receptors dendritic cells interferons rna helicases immunology animals genetics humans metabolism signal transduction

Interferon gene regulation: not all roads lead to Tolls. (2005)

Abstract Many infectious agents elicit a type I interferon response but, until recently, the molecular details that coordinate interferon (IFN)-alpha and -beta expression during infection were unknown. Innate immune pattern recognition receptors, including Toll-like receptors and cytoplasmic RNA helicases such as retinoic acid-inducible gene, that sense viral nucleic acids have been discovered. Using distinct mechanisms, these receptors trigger cellular signaling pathways, culminating in the activation of interferon regulatory factors that transcriptionally induce IFN-alpha and IFN-beta genes.
Collections Ireland -> Trinity College Dublin -> PubMed

Full list of authors on original publication

Katherine A Fitzgerald, Caroline A Jefferies

Experts in our system

1
Caroline A Jefferies
Royal College of Surgeons in Ireland
Total Publications: 50