Type

Journal Article

Authors

Aiden Corvin
Michael Gill
John L Waddington
Paul Scully
John Quinn
David Meagher
Sarah Clarke
Gary Donohoe
Jeanne Marie Nangle
Siobhan Schwaiger
and 2 others

Subjects

Biochemistry

Topics
up regulation genetic markers databases genetic chromosomes human pair 22 alleles case control studies apol1 protein human gene pool apolipoprotein l6 human genetic predisposition to disease apolipoproteins humans lipoproteins hdl schizophrenia dna polymorphism single nucleotide genetics genetic linkage genotype

Investigation of the apolipoprotein-L (APOL) gene family and schizophrenia using a novel DNA pooling strategy for public database SNPs. (2004)

Abstract We performed an extensive genetic association study of the six known apolipoprotein-L (APOL) genes and schizophrenia (SZ) using a novel DNA pooling strategy. The APOL genes are both positional and functional candidate genes for SZ. This gene family maps to chromosome 22q12.3, a region implicated by SZ linkage studies as likely to contain one or more SZ susceptibility genes. A recent gene expression study demonstrated up-regulation of APOL1, 2, and 4 in post-mortem brain samples from SZ patients compared to controls in two independent samples. To test for genetic association with SZ, we analyzed 143 SNPs from dbSNP from across the APOL genes in an Irish sample of 219 cases and 231 controls. Of these 143 SNPs, 51 (36%) were polymorphic in our Irish sample and were genotyped using a novel three-stage DNA pooling strategy. This strategy does not require the identification of a heterozygous individual for DNA pooling association analysis and is therefore very efficient when using public database SNPs. We found no evidence to support the hypothesis that genetic variation at the APOL genes contributes to SZ susceptibility in our sample.
Collections Ireland -> Trinity College Dublin -> PubMed

Full list of authors on original publication

Aiden Corvin, Michael Gill, John L Waddington, Paul Scully, John Quinn, David Meagher, Sarah Clarke, Gary Donohoe, Jeanne Marie Nangle, Siobhan Schwaiger and 2 others

Experts in our system

1
Aiden Corvin
Trinity College Dublin
Total Publications: 190
 
2
Michael Gill
Trinity College Dublin
Total Publications: 260
 
3
John L Waddington
Royal College of Surgeons in Ireland
Total Publications: 157
 
4
P J Scully
Royal College of Surgeons in Ireland
Total Publications: 10
 
5
David Meagher
University of Limerick
Total Publications: 101
 
6
Gary Donohoe
Trinity College Dublin
Total Publications: 130