Journal Article


Ziarih Hawi
Michael Gill
Michael Fitzgerald
Judith Conroy
Tim Becker
Christine Freitag
Roderick O'sullivan
Celine Mullins
Aiveen Kirley
Naomi Lowe
and 2 others



linkage disequilibrium male alleles review literature as topic adult monoamine oxidase attention deficit disorder with hyperactivity ireland nuclear family humans child enzymology minisatellite repeats female genotype genetics haplotypes dinucleotide repeats

Association analysis of the monoamine oxidase A and B genes with attention deficit hyperactivity disorder (ADHD) in an Irish sample: preferential transmission of the MAO-A 941G allele to affected children. (2005)

Abstract Pharmacological and genetic studies suggest the importance of the dopaminergic, serotonergic, and noradrenergic systems in the pathogenesis of attention deficit hyperactivity disorder (ADHD). Monoamine oxidases A and B (MAO-A and MAO-B) degrade biogenic amines such as dopamine and serotonin and thereby control the levels of these neurotransmitters in the central nervous system. We examined four polymorphisms in the MAO-A gene (30 bp promoter VNTR, CA microsatellite in intron 2, 941G/T SNP in exon 8, and A/G SNP in intron 12) as well as two markers in the MAO-B gene (CA microsatellite in intron 2 and T/C SNP in intron 13) for association with ADHD in an Irish sample of 179 nuclear families. TDT analysis of the examined MAO-A markers revealed a significant association of the more active MAO-A 941G allele with the disorder (chi2 = 5.1, P = 0.03, OR = 1.7). In addition, haplotype analysis revealed a significantly increased transmission of a haplotype consisting of the shorter allele of the promoter VNTR (allele 1), the 6-repeat allele of the CA microsatellite and the G-allele of the 941G/T SNP (famhap global statistic 34.54, P = 0.01) to ADHD cases. No significant distortion in the number of transmitted alleles was observed between the two examined MAO-B polymorphisms and ADHD. These findings suggest the importance of the 941G/T MAO-A polymorphism in the development of ADHD at least in the Irish population.
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Full list of authors on original publication

Ziarih Hawi, Michael Gill, Michael Fitzgerald, Judith Conroy, Tim Becker, Christine Freitag, Roderick O'sullivan, Celine Mullins, Aiveen Kirley, Naomi Lowe and 2 others

Experts in our system

Michael Gill
Trinity College Dublin
Total Publications: 294
Michael Fitzgerald
Trinity College Dublin
Total Publications: 101
Judith Conroy
University College Dublin
Total Publications: 24