Journal Article


Hugh Garavan
Robert Hester



physiopathology inhibition psychology cerebellum male gyrus cinguli memory frontal lobe middle aged adult mental processes humans cognition physiology cocaine related disorders decision making magnetic resonance imaging female

Executive dysfunction in cocaine addiction: evidence for discordant frontal, cingulate, and cerebellar activity. (2004)

Abstract Using a GO-NOGO response inhibition task in which working memory (WM) demands can be varied, we demonstrate that the compromised abilities of cocaine users to exert control over strong prepotent urges are associated with reduced activity in anterior cingulate and right prefrontal cortices, two regions thought to be critical for implementing cognitive control. Furthermore, unlike drug-naive controls, and opposite to the anterior cingulate pattern, cocaine users showed an over-reliance on the left cerebellum, a compensatory pattern previously seen in alcohol addiction. The results indicate that cocaine users find it difficult to inhibit their own actions, particularly when WM demands, which have been shown previously to increase during cue-induced craving for the drug, are increased. The results reveal a neuroanatomical basis for this dysexecutive component to addiction, supporting the suggested importance cognitive functions may play in prolonging abuse or predisposing users toward relapse.
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Full list of authors on original publication

Hugh Garavan, Robert Hester

Experts in our system

Hugh Garavan
Trinity College Dublin
Total Publications: 160
Robert Hester
Trinity College Dublin
Total Publications: 14