Type

Journal Article

Authors

Michael Gill
Michael Fitzgerald
Deirdre O'Donnell
Mary Mccarron
Irwin Waldman
Grainne Daly
Celine Mullins
Ziarih Hawi
Naomi Lowe
Aiveen Kirley

Subjects

Biochemistry

Topics
nerve tissue proteins attention deficit disorder with hyperactivity male methylphenidate membrane transport proteins membrane glycoproteins ireland dopamine plasma membrane transport proteins slc6a3 protein human humans pharmacology child drug therapy female genetics central nervous system stimulants

Association of the 480 bp DAT1 allele with methylphenidate response in a sample of Irish children with ADHD. (2003)

Abstract Several studies have implicated the dopamine transporter gene (DAT1) as conferring susceptibility to attention deficit hyperactivity disorder (ADHD), in particular, a VNTR situated at the 3' end of the gene. In addition, the 10-repeat VNTR allele associated with ADHD has been reported to be associated with an over-active transporter protein (DAT). Thus children possessing this variant might be particularly responsive to methylphenidate, a drug known to act by blocking DAT. We have examined this hypothesis and now report an association between the 10-repeat VNTR DAT1 polymorphism and retrospectively rated methylphenidate response in a sample of 119 Irish children with ADHD (chi(2) = 7.918, df = 1, P = 0.005). Our findings suggest a role for the 10-repeat DAT1 risk allele in medication response and may help to predict positive clinical outcome in ADHD.
Collections Ireland -> Trinity College Dublin -> PubMed

Full list of authors on original publication

Michael Gill, Michael Fitzgerald, Deirdre O'Donnell, Mary Mccarron, Irwin Waldman, Grainne Daly, Celine Mullins, Ziarih Hawi, Naomi Lowe, Aiveen Kirley

Experts in our system

1
Michael Gill
Trinity College Dublin
Total Publications: 260
 
2
Michael Fitzgerald
Trinity College Dublin
Total Publications: 90
 
3
Mary Mccarron
Trinity College Dublin
Total Publications: 52
 
4
Ziarih Hawi
Trinity College Dublin
Total Publications: 28