Type

Journal Article

Authors

E A Stein
R A P Roche
K Murphy
T J Ross
H Garavan

Subjects

Biochemistry

Topics
attention adult pattern recognition visual humans reaction time anatomy histology dominance cerebral neural inhibition female image processing computer assisted gyrus cinguli echo planar imaging male putamen nerve net frontal lobe middle aged imaging three dimensional brain mapping thalamus physiology electroencephalography psychomotor performance serial learning cerebral cortex

Dissociable executive functions in the dynamic control of behavior: inhibition, error detection, and correction. (2002)

Abstract The present study employed event-related fMRI and EEG to investigate the biological basis of the cognitive control of behavior. Using a GO/NOGO task optimized to produce response inhibitions, frequent commission errors, and the opportunity for subsequent behavioral correction, we identified distinct cortical areas associated with each of these specific executive processes. Two cortical systems, one involving right prefrontal and parietal areas and the second regions of the cingulate, underlay inhibitory control. The involvement of these two systems was predicated upon the difficulty or urgency of the inhibition and each was employed to different extents by high- and low-absent-minded subjects. Errors were associated with medial activation incorporating the anterior cingulate and pre-SMA while behavioral alteration subsequent to errors was associated with both the anterior cingulate and the left prefrontal cortex. Furthermore, the EEG data demonstrated that successful response inhibition depended upon the timely activation of cortical areas as predicted by race models of response selection. The results highlight how higher cognitive functions responsible for behavioral control can result from the dynamic interplay of distinct cortical systems.
Collections Ireland -> Trinity College Dublin -> PubMed

Full list of authors on original publication

E A Stein, R A P Roche, K Murphy, T J Ross, H Garavan

Experts in our system

1
Keith J. Murphy
University College Dublin
Total Publications: 37
 
2
Hugh Garavan
Trinity College Dublin
Total Publications: 160