Type

Journal Article

Authors

M Gill
M Fitzgerald
Z Hawi
G Daly

Subjects

Biochemistry

Topics
child preschool nerve tissue proteins receptors dopamine d1 nuclear family adult genetic predisposition to disease carrier proteins dopamine plasma membrane transport proteins slc6a3 protein human humans dopamine beta hydroxylase attention deficit disorder with hyperactivity membrane transport proteins polymorphism genetic adolescent receptors dopamine d5 membrane glycoproteins child genetics drd5 protein human chromosome mapping odds ratio

Mapping susceptibility loci in attention deficit hyperactivity disorder: preferential transmission of parental alleles at DAT1, DBH and DRD5 to affected children. (1999)

Abstract Attention deficit hyperactivity disorder (ADHD) is a common disorder of childhood characterized by inattention, excessive motor activity, impulsivity, and distractibility. It is associated with serious disability in children, adolescents and adults. The etiology of the disorder is unknown, but it has a strong genetic component. Pharmacological and biochemical studies have suggested that dopaminergic and noradrenergic systems are involved. Using a sample of affected children and their parents we have found preferential transmission of alleles at polymorphisms at the dopamine transporter (DAT1), RR=1.2 (1.05-1.37), P=0.006, re-confirming and extending our previous findings for DAT1 (new sample one-tailed P=0.039); dopamine-beta-hydroxylase (DBH), RR=1.31 (1.09-1.56), P=0.0027; and the dopamine D5 receptor (DRD5), RR=1.67 (1.29-2.15), P=0.00005. Transmission of the 'associated' alleles at DAT1 and DBH is stronger in familial cases, RR(DAT1)=1.29 (1.04-1.59), RR(DBH)=1.49 (1.10-2.00), but for DRD5, transmission is stronger in non-familial cases, RR=1.59 (1.05-2.42). TDT analysis of complete trios supports the HHRR analysis, with P<0.05, for DAT1 P<0.005 and DBH and P<0.01 for DRD5. Attributable fractions for DAT1, DBH and DRD5 are calculated at 0.08, 0.12 and 0.20 respectively.
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Full list of authors on original publication

M Gill, M Fitzgerald, Z Hawi, G Daly

Experts in our system

1
Michael Gill
Trinity College Dublin
Total Publications: 260
 
2
Michael Fitzgerald
Trinity College Dublin
Total Publications: 90
 
3
Ziarih Hawi
Trinity College Dublin
Total Publications: 28