Type

Journal Article

Authors

C Ryan
D Sheils
M Lawler
D J McConnell
E M Sharp
M M Humphries
D G Bradley
P Kenna
G J Farrar
P McWilliam

Subjects

Biochemistry

Topics
pedigree genetic linkage recombination genetic humans retinitis pigmentosa chromosome mapping female genetics lod score genes dominant male chromosomes human pair 3 polymorphism genetic genetic markers

Autosomal dominant retinitis pigmentosa (ADRP): localization of an ADRP gene to the long arm of chromosome 3. (1989)

Abstract Members of a large pedigree of Irish origin presenting with early onset Type I autosomal dominant retinitis pigmentosa (ADRP) have been typed for D3S47 (C17), a polymorphic marker from the long arm of chromosome 3. Significant, tight linkage of ADRP to D3S47, with a lod score of 14.7 maximizing at 0.00 recombination, has been obtained, hence localizing the ADRP gene (RP1) segregating in this pedigree to 3q.
Collections Ireland -> Trinity College Dublin -> PubMed

Full list of authors on original publication

C Ryan, D Sheils, M Lawler, D J McConnell, E M Sharp, M M Humphries, D G Bradley, P Kenna, G J Farrar, P McWilliam

Experts in our system

1
Cristín Ryan
University College Cork
Total Publications: 118
 
2
Mark Lawler
Trinity College Dublin
Total Publications: 38
 
3
Marian M Humphries
Trinity College Dublin
Total Publications: 43
 
4
Daniel Bradley
Trinity College Dublin
Total Publications: 84
 
5
Paul F Kenna
Trinity College Dublin
Total Publications: 62
 
6
G Jane Farrar
Trinity College Dublin
Total Publications: 64