Type

Journal Article

Authors

Douwe van Sinderen
Marco Ventura
Mary O'Connell Motherway
Muireann Egan

Subjects

Microbiology

Topics
plasmids oligonucleotide array sequence analysis culture media n acetylneuraminic acid sequence analysis dna multigene family bifidobacterium dna fragmentation genetics dna bacterial metabolism

Metabolism of sialic acid by Bifidobacterium breve UCC2003. (2014)

Abstract Bifidobacteria constitute a specific group of commensal bacteria that inhabit the gastrointestinal tracts of humans and other mammals. Bifidobacterium breve UCC2003 has previously been shown to utilize several plant-derived carbohydrates that include cellodextrins, starch, and galactan. In the present study, we investigated the ability of this strain to utilize the mucin- and human milk oligosaccharide (HMO)-derived carbohydrate sialic acid. Using a combination of transcriptomic and functional genomic approaches, we identified a gene cluster dedicated to the uptake and metabolism of sialic acid. Furthermore, we demonstrate that B. breve UCC2003 can cross feed on sialic acid derived from the metabolism of 3'-sialyllactose, an abundant HMO, by another infant gut bifidobacterial strain, Bifidobacterium bifidum PRL2010.
Collections Ireland -> University College Cork -> PubMed

Full list of authors on original publication

Douwe van Sinderen, Marco Ventura, Mary O'Connell Motherway, Muireann Egan

Experts in our system

1
Douwe van Sinderen
University College Cork
 
2
Marco Ventura
University College Cork
Total Publications: 31
 
3
Mary O'Connell Motherway
University College Cork
Total Publications: 18
 
4
Muireann Egan
University College Cork
Total Publications: 6