Type

Journal Article

Authors

Colin Hill
Fergus Shanahan
Alan Desmond
James P Dalton

Subjects

Microbiology

Topics
polymorphism single nucleotide young adult aged middle aged adult humans adolescent carrier proteins female interleukin 12 subunit p40 microbiology il12b protein human paratuberculosis complications crohn disease mycobacterium avium subsp paratuberculosis genetics atg16l1 protein human genetic association studies male isolation purification

Detection of Mycobacterium avium subspecies paratuberculosis in patients with Crohn's disease is unrelated to the presence of single nucleotide polymorphisms rs2241880 (ATG16L1) and rs10045431 (IL12B). (2013)

Abstract Mycobacterium avium subspecies paratuberculosis (MAP) has been controversially linked with Crohn's disease (CD). Detection of MAP in CD has been highly variable, and one explanation might be the genetic heterogeneity of this syndrome. Many of the single nucleotide polymorphisms (SNPs) linked with CD are contained within genes that are associated with bacterial handling in general, and some are specifically implicated in susceptibility to mycobacterial disease. We tested a cohort of IBD patients (n = 149) to determine whether the presence of MAP was associated with a selection of these SNPs. Blood samples from CD patients (n = 84), ulcerative colitis (UC, n = 65) patients and healthy controls (n = 55) were examined for the presence of MAP and SNPs in ATG16L1, IL12B, NOD2/CARD15, NKx2-3, IL23R and IRGM. Statistical analysis was then used to determine whether there was any association between the presence of MAP and these SNPs. MAP, rs2241880 (ATG16L1) and rs10045431 (IL12B) were found to be significantly associated with CD. The presence of MAP was not related to the status of the SNPs in ATG16L1 or IL12B. We have found no evidence for the contribution of these SNPs to the presence of MAP in CD patients.
Collections Ireland -> University College Cork -> PubMed

Full list of authors on original publication

Colin Hill, Fergus Shanahan, Alan Desmond, James P Dalton

Experts in our system

1
Colin Hill
University College Cork
Total Publications: 351
 
2
Fergus Shanahan
University College Cork
Total Publications: 237
 
3
Alan Desmond
University College Cork
Total Publications: 8