Type

Journal Article

Authors

Colin Hill
Julian R Marchesi
Roy D. Sleator
Eamonn P Culligan

Subjects

Microbiology

Topics
metagenomics drug discovery metagenome therapeutic use isolation purification biological products environmental microbiology humans genetic association studies

Metagenomics and novel gene discovery: promise and potential for novel therapeutics. (2013)

Abstract Metagenomics provides a means of assessing the total genetic pool of all the microbes in a particular environment, in a culture-independent manner. It has revealed unprecedented diversity in microbial community composition, which is further reflected in the encoded functional diversity of the genomes, a large proportion of which consists of novel genes. Herein, we review both sequence-based and functional metagenomic methods to uncover novel genes and outline some of the associated problems of each type of approach, as well as potential solutions. Furthermore, we discuss the potential for metagenomic biotherapeutic discovery, with a particular focus on the human gut microbiome and finally, we outline how the discovery of novel genes may be used to create bioengineered probiotics.
Collections Ireland -> University College Cork -> PubMed

Full list of authors on original publication

Colin Hill, Julian R Marchesi, Roy D. Sleator, Eamonn P Culligan

Experts in our system

1
Colin Hill
University College Cork
Total Publications: 351
 
2
Julian R Marchesi
University College Cork
Total Publications: 40
 
3
Roy D. Sleator
University College Cork
Total Publications: 44
 
4
Eamonn P Culligan
University College Cork
Total Publications: 13