Journal Article


Douwe van Sinderen
John P Morrissey
Jennifer Mahony
Sarah Crowley



physiology antibiosis rhizopus aspergillus fumigatus genetics lactobacillus plantarum metabolism hyphae antifungal agents gene expression profiling drug effects growth development spores bacterial

Transcriptomic and morphological profiling of Aspergillus fumigatus Af293 in response to antifungal activity produced by Lactobacillus plantarum 16. (2013)

Abstract The morphological effects of an antifungal activity produced by Lactobacillus plantarum 16, a malt-production steep water isolate, on two food-associated fungi were examined microscopically. Spore germination was completely inhibited in Aspergillus fumigatus and Rhizopus stolonifer upon treatment with concentrated cell-free supernatant (cCFS) of strain 16. Furthermore, addition of antifungal cCFS to germ tubes and hyphae halted further development compared to untreated controls. Transcriptome analysis of A. fumigatus Af293 following exposure to antifungal cCFS revealed a number of genes with altered transcription involved in a variety of cellular functions, most notably cell metabolism, suggesting a global metabolic shutdown and subsequent cell death. Increased transcription of the global regulator LaeA was also observed indicating that exposure to the antifungal activity caused a cellular stress response.
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Full list of authors on original publication

Douwe van Sinderen, John P Morrissey, Jennifer Mahony, Sarah Crowley

Experts in our system

John P Morrissey
University College Cork
Total Publications: 71
Jennifer Mahony
University College Cork
Total Publications: 87