Type

Journal Article

Authors

Roy D. Sleator
Colin Hill
Julian R Marchesi
Eamonn P Culligan

Subjects

Microbiology

Topics
genomics drug effects genetics gastrointestinal tract metagenome microbiology computational biology osmotic pressure humans bacteria genes bacterial stress physiological

Mining the human gut microbiome for novel stress resistance genes. (2012)

Abstract With the rapid advances in sequencing technologies in recent years, the human genome is now considered incomplete without the complementing microbiome, which outnumbers human genes by a factor of one hundred. The human microbiome, and more specifically the gut microbiome, has received considerable attention and research efforts over the past decade. Many studies have identified and quantified "who is there?," while others have determined some of their functional capacity, or "what are they doing?" In a recent study, we identified novel salt-tolerance loci from the human gut microbiome using combined functional metagenomic and bioinformatics based approaches. Herein, we discuss the identified loci, their role in salt-tolerance and their importance in the context of the gut environment. We also consider the utility and power of functional metagenomics for mining such environments for novel genes and proteins, as well as the implications and possible applications for future research.
Collections Ireland -> University College Cork -> PubMed

Full list of authors on original publication

Roy D. Sleator, Colin Hill, Julian R Marchesi, Eamonn P Culligan

Experts in our system

1
Roy D. Sleator
University College Cork
Total Publications: 44
 
2
Colin Hill
University College Cork
Total Publications: 351
 
3
Julian R Marchesi
University College Cork
Total Publications: 40
 
4
Eamonn P Culligan
University College Cork
Total Publications: 13