Type

Journal Article

Authors

Colin Hill
Cormac G M Gahan
Maire Begley
Sinéad Heuston

Subjects

Microbiology

Topics
humans pharmacology bacterial proteins drug effects bacteria bacterial infections terpenes pathogenicity microbiology animals genetics metabolism anti bacterial agents biosynthetic pathways isolation purification drug therapy

Isoprenoid biosynthesis in bacterial pathogens. (2012)

Abstract Isoprenoid biosynthesis is essential for cell survival. Over 35 000 isoprenoid molecules have been identified to date in the three domains of life (bacteria, archaea and eukaryotes), and these molecules are involved in a wide variety of vital biological functions. Isoprenoids may be synthesized via one of two independent nonhomologous pathways, the classical mevalonate pathway or the alternative 2C-methyl-D-erythritol 4-phosphate (MEP) pathway. Given that isoprenoids are indispensable, enzymes involved in their production have been investigated as potential drug targets. It has also been observed that the MEP pathway intermediate 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (HMB-PP) can activate human Vγ9/Vδ2 T cells. Herein we review isoprenoid biosynthesis in bacterial pathogens. The role of isoprenoid biosynthesis pathways in host-pathogen interactions (virulence potential and immune stimulation) is examined. Finally, the design of antimicrobial drugs that target isoprenoid biosynthesis pathways is discussed.
Collections Ireland -> University College Cork -> PubMed

Full list of authors on original publication

Colin Hill, Cormac G M Gahan, Maire Begley, Sinéad Heuston

Experts in our system

1
Colin Hill
University College Cork
Total Publications: 351
 
2
Cormac G M Gahan
University College Cork
Total Publications: 109
 
3
Maire Begley
University College Cork
Total Publications: 27