Journal Article


R Paul Ross
Douglas A Mitchell
Colin Hill
Paul D. Cotter
Evelyn M. Molloy



operon virulence genetics streptolysins microbiology bacterial proteins metabolism humans streptococcal infections streptococcus pyogenes pathogenicity streptolysin s

Streptolysin S-like virulence factors: the continuing sagA. (2011)

Abstract Streptolysin S (SLS) is a potent cytolytic toxin and virulence factor that is produced by nearly all Streptococcus pyogenes strains. Despite a 100-year history of research on this toxin, it has only recently been established that SLS is just one of an extended family of post-translationally modified virulence factors (the SLS-like peptides) that are produced by some streptococci and other Gram-positive pathogens, such as Listeria monocytogenes and Clostridium botulinum. In this Review, we describe the identification, genetics, biochemistry and various functions of SLS. We also discuss the shared features of the virulence-associated SLS-like peptides, as well as their place within the rapidly expanding family of thiazole/oxazole-modified microcins (TOMMs).
Collections Ireland -> University College Cork -> PubMed

Full list of authors on original publication

R Paul Ross, Douglas A Mitchell, Colin Hill, Paul D. Cotter, Evelyn M. Molloy

Experts in our system

R Paul Ross
Total Publications: 441
Colin Hill
University College Cork
Total Publications: 351
Paul D. Cotter
Total Publications: 253