Type

Journal Article

Authors

R Paul Ross
Paul D. Cotter
Colin Hill
Des Field

Subjects

Microbiology

Topics
bacteria bacteriocins this review molecular sequence data amino acid sequence genetics metabolism bioengineering

The dawning of a 'Golden era' in lantibiotic bioengineering. (2010)

Abstract There are many examples of highly modified antimicrobial peptides in nature, many of which are non-ribosomally synthesized. However, the bacterial lantibiotics are produced as gene-encoded pre-peptides that are subsequently modified by dedicated enzyme systems to form extraordinarily potent inhibitors. Consequently, they are much more amenable to bioengineering which could lead to the generation of a new arsenal of potent antimicrobials. However, although bioengineering of these compounds has been underway for at least two decades, significant progress has only been reported in recent years. This review charts these recent developments which suggest that we are entering a 'Golden era' of lantibiotic bioengineering.
Collections Ireland -> University College Cork -> PubMed

Full list of authors on original publication

R Paul Ross, Paul D. Cotter, Colin Hill, Des Field

Experts in our system

1
R Paul Ross
Teagasc
Total Publications: 441
 
2
Paul D. Cotter
Teagasc
Total Publications: 253
 
3
Colin Hill
University College Cork
Total Publications: 351
 
4
Des Field
Teagasc
Total Publications: 30