Type

Journal Article

Authors

Cormac G M Gahan
Colin Hill
Paul W O’ Toole
Christian U Riedel
Yin Li
Sinead C Corr

Subjects

Microbiology

Topics
gram positive bacterial infections bacteriocins pathology biosynthesis mice anti infective agents drug effects spleen liver diseases pharmacology lactobacillus animals mutation prevention control genetics administration dosage microbiology

Bacteriocin production as a mechanism for the antiinfective activity of Lactobacillus salivarius UCC118. (2007)

Abstract The mechanisms by which probiotic strains enhance the health of the host remain largely uncharacterized. Here we demonstrate that Lactobacillus salivarius UCC118, a recently sequenced and genetically tractable probiotic strain of human origin, produces a bacteriocin in vivo that can significantly protect mice against infection with the invasive foodborne pathogen Listeria monocytogenes. A stable mutant of Lb. salivarius UCC118 that is unable to produce the Abp118 bacteriocin also failed to protect mice against infection with two strains of L. monocytogenes, EGDe and LO28, confirming that bacteriocin production is the primary mediator of protection against this organism. Furthermore, Lb. salivarius UCC118 did not offer any protection when mice were infected with a strain of L. monocytogenes expressing the cognate Abp118 immunity protein AbpIM, confirming that the antimicrobial effect is a result of direct antagonism between Lb. salivarius and the pathogen, mediated by the bacteriocin Abp118.
Collections Ireland -> University College Cork -> PubMed

Full list of authors on original publication

Cormac G M Gahan, Colin Hill, Paul W O’ Toole, Christian U Riedel, Yin Li, Sinead C Corr

Experts in our system

1
Cormac G M Gahan
University College Cork
Total Publications: 109
 
2
Colin Hill
University College Cork
Total Publications: 351
 
3
Paul W O’ Toole
University College Cork
Total Publications: 92
 
4
Sinead C Corr
Trinity College Dublin
Total Publications: 24