Type

Journal Article

Authors

Colin Hill
Tanya Clifford
Roy D. Sleator

Subjects

Microbiology

Topics
intestines models biological osmolar concentration physiopathology water electrolyte balance bacterial proteins sigma factor metabolism listeriosis sigb protein bacteria microbiology animals genetics gastrointestinal tract environmental microbiology

Gut osmolarity: a key environmental cue initiating the gastrointestinal phase of Listeria monocytogenes infection? (2007)

Abstract In addition to the severe invasive systemic disease of listeriosis, recent evidence suggests that the Gram-positive intracellular bacterial pathogen Listeria monocytogenes is also a causative agent of febrile gastroenteritis. We examined the listerial response to stresses normally encountered in the upper small intestine and demonstrate that osmotic stress appears to be at the top of the hierarchy of stress responses during gastrointestinal residence. Furthermore, we suggest that the increased osmolarity of the gastrointestinal lumen may be interpreted as an environmental cue signalling gut entry and that the underlying genetic element governing this response is the alternative stress sigma factor sigma(B).
Collections Ireland -> University College Cork -> PubMed

Full list of authors on original publication

Colin Hill, Tanya Clifford, Roy D. Sleator

Experts in our system

1
Colin Hill
University College Cork
Total Publications: 351
 
2
Tanya Clifford
University College Cork
Total Publications: 4
 
3
Roy D. Sleator
University College Cork
Total Publications: 44