Journal Article


C Hill
R P Ross
O McAuliffe



peptides sulfides bacteriocins alanine biosynthesis analogs derivatives lanthionine pharmacology molecular sequence data anti bacterial agents chemistry genetics amino acid sequence

Lantibiotics: structure, biosynthesis and mode of action. (2001)

Abstract The lantibiotics are a group of ribosomally synthesised, post-translationally modified peptides containing unusual amino acids, such as dehydrated and lanthionine residues. This group of bacteriocins has attracted much attention in recent years due to the success of the well characterised lantibiotic, nisin, as a food preservative. Numerous other lantibiotics have since been identified and can be divided into two groups on the basis of their structures, designated type-A and type-B. To date, many of these lantibiotics have undergone extensive characterisation resulting in an advanced understanding of them at both the structural and mechanistic level. This review outlines some of the more recent developments in the biochemistry, genetics and mechanism of action of these peptides.
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Full list of authors on original publication

C Hill, R P Ross, O McAuliffe

Experts in our system

Colin Hill
University College Cork
Total Publications: 351
R Paul Ross
Total Publications: 441
Olivia McAuliffe
Total Publications: 64