Journal Article


D Krause
C Fennelly
R O'Connor



cell survival models biological physiology tumor cells cultured humans caenorhabditis elegans apoptosis insulin like growth factor i receptor igf type 1 mutagenesis protein structure tertiary animals metabolism signal transduction

Regulation of survival signals from the insulin-like growth factor-I receptor. (2000)

Abstract Suppression of apoptosis by survival factors is important for the maintenance of normal tissue homoeostasis and the response to infection or injury. Survival factors such as insulin-like growth factor-I (IGF-I) initiate a signalling cascade that starts by tyrosine phosphorylation of substrates leading to the activation of serine kinases that modulate the activity of members of the Bcl-2 family, which regulates the apoptotic machinery in most cells. Tumour cells often have enhanced survival mechanisms due either to up-regulation of the IGF-I receptor and its ligands or to loss of function of a phosphatase (PTEN) that regulates part of this survival pathway. The C-terminus of the IGF-I receptor appears to be a regulatory domain for the anti-apoptotic activity of this receptor, and certain residues within the C-terminus are essential for this regulatory activity. Knowledge of the proteins and pathways, which interact with these C-terminal domains, should lead us to ways of modulating IGF-I-mediated survival in tumours.
Collections Ireland -> University College Cork -> PubMed

Full list of authors on original publication

D Krause, C Fennelly, R O'Connor

Experts in our system

Robert O'Connor
Dublin City University
Total Publications: 74