Journal Article


R P Ross
C Hill
M Galvin



lacticin 481 pharmacology pathogenicity gram positive bacteria microbial sensitivity tests bacterial proteins drug effects bacteriocins

Lacticin 3147 displays activity in buffer against gram-positive bacterial pathogens which appear insensitive in standard plate assays. (1999)

Abstract Lacticin 3147 is a broad-spectrum bacteriocin produced by Lactococcus lactis subsp. lactis DPC3147, which has been shown to be active against a range of food-borne bacteria. The reported inhibitory range for lacticin is extended to include methicillin-resistant Staphylococcus aureus, vancomycin-resistant Enterococcus faecalis, penicillin-resistant Pneumococcus, Propionibacterium acne and Streptococcus mutans. This extended host range is not obvious from traditional agar plate-based methods, but reductions in bacterial cell numbers by up to 6 log10 cfu ml-1 was observed after 2 h in time-kill curve studies conducted in broth, suggesting that the bacteriocin may have potential as a therapeutic agent in the treatment of human infections.
Collections Ireland -> University College Cork -> PubMed

Full list of authors on original publication

R P Ross, C Hill, M Galvin

Experts in our system

R Paul Ross
Total Publications: 441
Colin Hill
University College Cork
Total Publications: 351