Journal Article


C Hill
C G Gahan
N Emerson
L Marron



listeriosis stress physiological hot temperature listeria monocytogenes animals genetics mice disease models animal growth development mutation hydrogen ion concentration etiology pathogenicity mice inbred balb c virulence

A mutant of Listeria monocytogenes LO28 unable to induce an acid tolerance response displays diminished virulence in a murine model. (1997)

Abstract Exposing Listeria monocytogenes LO28 to sublethal pH induces protection against normally lethal pH conditions, a phenomenon known as the acid tolerance response. We identified a mutant, L. monocytogenes ATR1, which is incapable of inducing such tolerance, either against low pH or against any other stress tested. The virulence of this mutant was considerably decreased, suggesting that the acid tolerance response contributes to in vivo survival of L. monocytogenes.
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Full list of authors on original publication

C Hill, C G Gahan, N Emerson, L Marron

Experts in our system

Colin Hill
University College Cork
Total Publications: 351
Cormac G M Gahan
University College Cork
Total Publications: 109