Type

Journal Article

Authors

Hannelore Daniel
Michael J Gibney
Iwona Traczyk
J Alfredo Martínéz
Yannis Manios
Wim H M Saris
Julie A Lovegrove
Marianne C Walsh
Lorraine Brennan
Eileen R Gibney
and 18 others

Subjects

Physiotherapy & Sport

Topics
food intake fatty acid blood training health snp mathematical modelling profiles

Predicting fatty acid profiles in blood based on food intake and the FADS1 rs174546 SNP. (2015)

Abstract A high intake of n-3 PUFA provides health benefits via changes in the n-6/n-3 ratio in blood. In addition to such dietary PUFAs, variants in the fatty acid desaturase 1 (FADS1) gene are also associated with altered PUFA profiles. We used mathematical modelling to predict levels of PUFA in whole blood, based on MHT and bolasso selected food items, anthropometric and lifestyle factors, and the rs174546 genotypes in FADS1 from 1,607 participants (Food4Me Study). The models were developed using data from the first reported time point (training set) and their predictive power was evaluated using data from the last reported time point (test set). Amongst other food items, fish, pizza, chicken and cereals were identified as being associated with the PUFA profiles. Using these food items and the rs174546 genotypes as predictors, models explained 26% to 43% of the variability in PUFA concentrations in the training set and 22% to 33% in the test set. Selecting food items using MHT is a valuable contribution to determine predictors, as our models' predictive power is higher compared to analogue studies. As unique feature, we additionally confirmed our models' power based on a test set. This article is protected by copyright. All rights reserved.
Collections Ireland -> University College Dublin -> PubMed

Full list of authors on original publication

Hannelore Daniel, Michael J Gibney, Iwona Traczyk, J Alfredo Martínéz, Yannis Manios, Wim H M Saris, Julie A Lovegrove, Marianne C Walsh, Lorraine Brennan, Eileen R Gibney and 18 others

Experts in our system

1
Hannelore Daniel
University College Dublin
Total Publications: 33
 
2
Michael J Gibney
University College Dublin
Total Publications: 102
 
3
Yannis Manios
University College Dublin
Total Publications: 38
 
4
Wim H M Saris
University College Dublin
Total Publications: 39
 
5
Julie A Lovegrove
University College Dublin
Total Publications: 46
 
6
Marianne C Walsh
University College Dublin
Total Publications: 51
 
7
Lorraine Brennan
University College Dublin
Total Publications: 166
 
8
Eileen R Gibney
University College Dublin
Total Publications: 98