Journal Article


Helen M Roche
Melissa J Morine
Michael J Gibney
Lorraine Brennan
Eileen R Gibney
Marianne Walsh
Miriam F Ryan
Ciara Morris
Eugene T Dillon
Colm M O Grada
and 1 others


Medicine & Nursing

acute health inflammatory response linear mixed models blood cells body mass index network analysis inflammation

Body mass index mediates inflammatory response to acute dietary challenges. (2015)

Abstract Acute metabolic challenges provide an opportunity to identify mechanisms of metabolic and nutritional health. In this study, we assessed the transcriptomic response to oral glucose and lipid challenges in a cohort of individuals ranging in age and BMI. The main goal is to identify whether BMI can mediate the metabolic and transcriptional response to dietary challenges, and the differences between lipid and glucose tests. 214 healthy adults were assigned to the challenges and 23 individuals were selected for further transcriptomic proofing, using microarrays analysis of peripheral blood mononuclear cells. Through linear mixed models and network analysis, different sets of transcripts and pathways were identified that responded to the challenges depending on BMI. Different transcripts that responded to the lipid and glucose tests, independently of BMI, were also identified. In the network analysis, inflammatory and adhesion processes were strongly represented for both challenges. Our results indicate that BMI is strongly linked to the transcriptomic and metabolic response to acute challenges. The emerging biological processes are mainly inflammation related pathways, highlighting an interconnection between obesity, inflammation/adhesion and response to nutritional challenge. The comparison between lipid and glucose challenges shows how these trigger a substantially different molecular response. This article is protected by copyright. All rights reserved.
Collections Ireland -> University College Dublin -> PubMed

Full list of authors on original publication

Helen M Roche, Melissa J Morine, Michael J Gibney, Lorraine Brennan, Eileen R Gibney, Marianne Walsh, Miriam F Ryan, Ciara Morris, Eugene T Dillon, Colm M O Grada and 1 others

Experts in our system

Helen M. Roche
University College Dublin
Total Publications: 105
Michael J Gibney
University College Dublin
Total Publications: 102
Lorraine Brennan
University College Dublin
Total Publications: 166
Eileen R Gibney
University College Dublin
Total Publications: 98
Marianne C Walsh
University College Dublin
Total Publications: 51
Miriam Ryan
University College Dublin
Total Publications: 34
Eugene T Dillon
University College Dublin