Type

Journal Article

Authors

Tomáš Paus
Zdenka Pausova
George Davey Smith
Gunter Schumann
Nic J Timpson
Robert Whelan
Henrik Walter
Michael N Smolka
Marcella Rietschel
Luise Poustka
and 28 others

Subjects

Psychiatry

Topics
longitudinal study data analysis follow up genetic loci brain cannabis use parents and children 5 years

Early Cannabis Use, Polygenic Risk Score for Schizophrenia and Brain Maturation in Adolescence. (2015)

Abstract Cannabis use during adolescence is known to increase the risk for schizophrenia in men. Sex differences in the dynamics of brain maturation during adolescence may be of particular importance with regard to vulnerability of the male brain to cannabis exposure. To evaluate whether the association between cannabis use and cortical maturation in adolescents is moderated by a polygenic risk score for schizophrenia. Observation of 3 population-based samples included initial analysis in 1024 adolescents of both sexes from the Canadian Saguenay Youth Study (SYS) and follow-up in 426 adolescents of both sexes from the IMAGEN Study from 8 European cities and 504 male youth from the Avon Longitudinal Study of Parents and Children (ALSPAC) based in England. A total of 1577 participants (aged 12-21 years; 899 [57.0%] male) had (1) information about cannabis use; (2) imaging studies of the brain; and (3) a polygenic risk score for schizophrenia across 108 genetic loci identified by the Psychiatric Genomics Consortium. Data analysis was performed from March 1 through December 31, 2014. Cortical thickness derived from T1-weighted magnetic resonance images. Linear regression tests were used to assess the relationships between cannabis use, cortical thickness, and risk score. Across the 3 samples of 1574 participants, a negative association was observed between cannabis use in early adolescence and cortical thickness in male participants with a high polygenic risk score. This observation was not the case for low-risk male participants or for the low- or high-risk female participants. Thus, in SYS male participants, cannabis use interacted with risk score vis-à-vis cortical thickness (P = .009); higher scores were associated with lower thickness only in males who used cannabis. Similarly, in the IMAGEN male participants, cannabis use interacted with increased risk score vis-à-vis a change in decreasing cortical thickness from 14.5 to 18.5 years of age (t137 = -2.36; P = .02). Finally, in the ALSPAC high-risk group of male participants, those who used cannabis most frequently (≥61 occasions) had lower cortical thickness than those who never used cannabis (difference in cortical thickness, 0.07 [95% CI, 0.01-0.12]; P = .02) and those with light use (<5 occasions) (difference in cortical thickness, 0.11 [95% CI, 0.03-0.18]; P = .004). Cannabis use in early adolescence moderates the association between the genetic risk for schizophrenia and cortical maturation among male individuals. This finding implicates processes underlying cortical maturation in mediating the link between cannabis use and liability to schizophrenia.
Collections Ireland -> University College Dublin -> PubMed

Full list of authors on original publication

Tomáš Paus, Zdenka Pausova, George Davey Smith, Gunter Schumann, Nic J Timpson, Robert Whelan, Henrik Walter, Michael N Smolka, Marcella Rietschel, Luise Poustka and 28 others

Experts in our system

1
Tomas Paus
Trinity College Dublin
Total Publications: 62
 
2
Gunter Schumann
Trinity College Dublin
Total Publications: 65
 
3
Robert Whelan
Trinity College Dublin
Total Publications: 80
 
4
Michael N Smolka
Trinity College Dublin
Total Publications: 65
 
5
Marcella Rietschel
Trinity College Dublin
Total Publications: 40