Journal Article


Peter Andersen
Jan P Christensen
Joseph P Cassidy
Else Marie Agger
Truc Hoang



interleukin 2 cd4 t cells cytokine production protein energy malnutrition steady state tumor necrosis factor alpha infectious diseases mycobacterium tuberculosis

Protein Energy Malnutrition during Vaccination Has Limited Influence on Vaccine Efficacy but Abolishes Immunity if Administered during Mycobacterium tuberculosis Infection. (2014)

Abstract Protein energy malnutrition (PEM) increases susceptibility to infectious diseases, including tuberculosis (TB), but it is not clear how PEM influences vaccine-promoted immunity to TB. We demonstrate that PEM during low-level steady-state TB infection in a mouse model results in rapid relapse of Mycobacterium tuberculosis, as well as increased pathology, in both Mycobacterium bovis BCG-vaccinated and unvaccinated animals. PEM did not change the overall numbers of CD4 T cells in BCG-vaccinated animals but resulted in an almost complete loss of antigen-specific cytokine production. Furthermore, there was a change in cytokine expression characterized by a gradual loss of multifunctional antigen-specific CD4 T cells and an increased proportion of effector cells expressing gamma interferon and tumor necrosis factor alpha (IFN-γ(+) TNF-α(+) and IFN-γ(+) cells). PEM during M. tuberculosis infection completely blocked the protection afforded by the H56-CAF01 subunit vaccine, and this was associated with a very substantial loss of the interleukin-2-positive memory CD4 T cells promoted by this vaccine. Similarly, PEM during the vaccination phase markedly reduced the H56-CAF01 vaccine response, influencing all cytokine-producing CD4 T cell subsets, with the exception of CD4 T cells positive for TNF-α only. Importantly, this impairment was reversible and resupplementation of protein during infection rescued both the vaccine-promoted T cell response and the protective effect of the vaccine against M. tuberculosis infection.
Collections Ireland -> University College Dublin -> PubMed

Full list of authors on original publication

Peter Andersen, Jan P Christensen, Joseph P Cassidy, Else Marie Agger, Truc Hoang

Experts in our system

Peter Andersen
University College Dublin
Total Publications: 6
Joseph P. Cassidy
University College Dublin
Total Publications: 55
Else Marie Agger
University College Dublin
Total Publications: 4