Journal Article


Desmond C. Winter
P Ronan O'Connell
Mathew R Albert
John P Burke
Cillian Clancy


Medicine & Nursing

disease free survival pathology carcinoma humans adenoma surgery treatment outcome microsurgery proctoscopy rectum rectal neoplasms

Transanal endoscopic microsurgery versus standard transanal excision for the removal of rectal neoplasms: a systematic review and meta-analysis. (2015)

Abstract Transanal endoscopic microsurgery is the intraluminal excision of rectal lesions with the use of instrumentation to maintain a stable pneumorectum, enabling a magnified view of the target lesion. Despite suggested benefits over traditional transanal excision, there is no consensus on which technique is superior. The aim of the current study is to use meta-analytical techniques to compare transanal endoscopic microsurgery with transanal excision. A comprehensive literature search of PubMed, Embase, and The Cochrane Library was performed. All studies comparing transanal endoscopic microsurgery with transanal excision were included. Transanal endoscopic microsurgery was compared with transanal excision by using random-effects methods to combine data. Data are presented as ORs with 95% CIs. The main outcomes measured were postoperative complication rate, negative microscopic margin rate, specimen fragmentation rate, and lesion recurrence. Six comparative series comparing outcomes following 927 local excisions were identified. There was no difference between techniques in postoperative complication rate (OR, 1.018; 95% CI, 0.658-1.575; p = 0.937). Transanal endoscopic microsurgery had a higher rate of negative microscopic margins in comparison with transanal excision (OR, 5.281; 95% CI, 3.201-8.712; p < 0.001). Transanal endoscopic microsurgery had a reduced rate of specimen fragmentation (OR, 0.096; 95% CI, 0.044-0.209; p < 0.001) and lesion recurrence (OR, 0.248; 95% CI, 0.154-0.401; p < 0.001) compared with transanal excision. There was no across-study heterogeneity for any end point. Most studies were retrospectively designed, and there were variations in patient populations and duration of follow-up. Available data are limited because of a lack of randomized controlled trials. However, based on current evidence, transanal endoscopic microsurgery is oncologically superior to transanal excision for the excision of rectal neoplasms.
Collections Ireland -> University College Dublin -> PubMed

Full list of authors on original publication

Desmond C. Winter, P Ronan O'Connell, Mathew R Albert, John P Burke, Cillian Clancy

Experts in our system

Desmond C. Winter
University College Dublin
Total Publications: 53
P R O'Connell
University College Dublin
Total Publications: 75
John P Burke
University of Limerick
Total Publications: 21