Type

Journal Article

Authors

José López-Miranda
Lorraine Brennan
Francisco Pérez-Jiménez
Helen M. Roche
Nieves Delgado-Casado
Antonio Camargo
Carmen Marin
Antonio Garcia-Rios
Pablo Pérez-Martínez
Javier Delgado-Lista
and 2 others

Subjects

Microbiology

Topics
blood male analogs derivatives aged antioxidants hippuric acid oxidative stress ubiquinone phenylacetylglycine coenzyme q10 urine biological markers aging dietary fats humans gene expression metabolomics beta carotene diet mediterranean hippurates administration dosage cross over studies female glycine dietary supplements genetics metabolism

Effects of the Mediterranean diet supplemented with coenzyme q10 on metabolomic profiles in elderly men and women. (2014)

Abstract Characterization of the variations in the metabolomic profiles of elderly people is a necessary step to understand changes associated with aging. This study assessed whether diets with different fat quality and supplementation with coenzyme Q10 (CoQ) affect the metabolomic profile in urine analyzed by proton nuclear magnetic resonance spectroscopy from elderly people. Ten participants received, in a cross-over design, four isocaloric diets for 4-week periods each: Mediterranean diet supplemented with CoQ (Med + CoQ diet); Mediterranean diet; Western diet rich in saturated fat diet; low-fat, high-carbohydrate diet enriched in n-3 polyunsaturated fat. Multivariate analysis showed differences between diets when comparing Med + CoQ diet and saturated fat diet, with greater hippurate urine levels after Med + CoQ diet and higher phenylacetylglycine levels after saturated fat diet in women. Following consumption of Med + CoQ, hippurate excretion was positively correlated with CoQ and β-carotene plasma levels and inversely related to Nrf2, thioredoxin, superoxide dismutase 1, and gp91(phox) subunit of NADPH oxidase gene expression. After saturated fat diet consumption, phenylacetylglycine excretion was inversely related to CoQ plasma level and positively correlated with isoprostanes urinary level. The association between hippurate excretion and antioxidant biomarkers along with the relationship between phenylacetylglycine excretion and oxidant biomarkers suggests that the long-term consumption of a Med + CoQ diet could be beneficial for healthy aging and a promising challenge in the prevention of processes related to chronic oxidative stress, such as cardiovascular and neurodegenerative disease.
Collections Ireland -> University College Dublin -> PubMed

Full list of authors on original publication

José López-Miranda, Lorraine Brennan, Francisco Pérez-Jiménez, Helen M. Roche, Nieves Delgado-Casado, Antonio Camargo, Carmen Marin, Antonio Garcia-Rios, Pablo Pérez-Martínez, Javier Delgado-Lista and 2 others

Experts in our system

1
José López-Miranda
University College Dublin
Total Publications: 18
 
2
Lorraine Brennan
University College Dublin
Total Publications: 166
 
3
Helen M. Roche
University College Dublin
Total Publications: 105
 
4
Antonio Camargo
University College Dublin
 
5
Carmen Marin
University College Dublin
 
6
Pablo Pérez-Martínez
University College Dublin
Total Publications: 12
 
7
Javier Delgado-Lista
University College Dublin