Journal Article


Fionnuala M McAuliffe
Michael E Foley
Gillian Canty
Rhona M Mahony
Jennifer M Walsh


Medicine & Nursing

maternal nutritional physiological phenomena cohort studies fetal blood physiopathology diet carbohydrate restricted body mass index etiology adiposity humans metabolism adult fetal macrosomia educational status glucose intolerance leptin insulin female prevention control pregnancy glycemic index blood birth weight pregnancy complications patient education as topic weight gain adverse effects secondary prevention insulin resistance

Identification of those most likely to benefit from a low-glycaemic index dietary intervention in pregnancy. (2014)

Abstract The present study is a secondary analysis of the ROLO study, a randomised control trial of a low-glycaemic index (GI) diet in pregnancy to prevent the recurrence of fetal macrosomia. The objectives of the present study were to identify which women are most likely to respond to a low-GI dietary intervention in pregnancy with respect to three outcome measures: birth weight; maternal glucose intolerance; gestational weight gain (GWG). In early pregnancy, 372 women had their mid-upper arm circumference recorded and BMI calculated. Concentrations of glucose, insulin and leptin were measured in early pregnancy and at 28 weeks. At delivery, infant birth weight was recorded and fetal glucose, C-peptide and leptin concentrations were measured in the cord blood. Women who benefited in terms of infant birth weight were shorter, with a lower education level. Those who maintained weight gain within the GWG guidelines were less overweight in both their first and second pregnancies, with no difference being observed in maternal height. Women who at 28 weeks of gestation developed glucose intolerance, despite the low-GI diet, had a higher BMI and higher glucose concentrations in early pregnancy with more insulin resistance. They also had significantly higher-interval pregnancy weight gain. For each analysis, women who responded to the intervention had lower leptin concentrations in early pregnancy than those who did not. These findings suggest that the maternal metabolic environment in early pregnancy is important in determining later risks of excessive weight gain and metabolic disturbance, whereas birth weight is mediated more by genetic factors. It highlights key areas, which warrant further interrogation before future pregnancy intervention studies, in particular, maternal education level and inter-pregnancy weight gain.
Collections Ireland -> University College Dublin -> PubMed

Full list of authors on original publication

Fionnuala M McAuliffe, Michael E Foley, Gillian Canty, Rhona M Mahony, Jennifer M Walsh

Experts in our system

Fionnuala M McAuliffe
University College Dublin
Total Publications: 176
Michael E Foley
University College Dublin
Total Publications: 25
Rhona Mahony
University College Dublin
Total Publications: 29
Jennifer M Walsh
University College Dublin
Total Publications: 27