Type

Journal Article

Authors

Glen Doherty
Hugh Mulcahy
Jacintha O'Sullivan
Diarmuid O'Donoghue
John Hyland
Diarmuid O'Shea
Kieran Sheahan
Edel McDermott
Anne White
Blathnaid Nolan
and 5 others

Subjects

Medicine & Nursing

Topics
all cause united kingdom cancer patients regression analysis lipid peroxidation odds ratio colorectal cancer cancer survival

Determinants of short- and long-term survival from colorectal cancer in very elderly patients. (2012)

Abstract Over 5100 colorectal cancers (CRCs) are diagnosed in the United Kingdom in 85 years and older age group per year but little is known of cancer progression in this group. We assessed clinical, pathological and molecular features of CRC with early and late mortality in such patients. Data were analysed in relation to early mortality and long-term survival in 90 consecutive patients with CRC aged 85 years or older in a single hospital. Patients not undergoing operation, those with an ASA score of III or greater and those with advanced tumour stage were more likely to die within 30 days. Regression analysis showed that 30 day mortality was independently related to failure to undergo resection (odds ratio (O.R.), 10.0; 95% confidence interval [C.I.], 1.7-58.2; p=0.01) and an ASA score of III or greater (O.R. 13.0; 95% C.I., 1.4-12.6; p=0.03). All cause three and five year survival were 47% and 23% respectively for patients who are alive 30 days after diagnosis. Three and five year relative survivals were 64% and 54%, respectively. Long-term outcome was independently related to tumour stage (relative risk [R.R.], 2; 95% C.I., 1.3-3.1; p=0.001), presence of co-morbid diseases (R.R., 2.8; 95% C.I., 1.3-6.0; p=0.007) and lipid peroxidation status (R.R., 2.9; 95% C.I., 1.1-7.5; p=0.025). An active multidisciplinary approach to the care of patients with CRC at the upper extreme of life is reasonable. It also seems sensible to individualise care based upon the extent of disease at diagnosis and the presence of co-morbid conditions. Further studies to examine the role of lipid peroxidation are warranted.
Collections Ireland -> University College Dublin -> PubMed

Full list of authors on original publication

Glen Doherty, Hugh Mulcahy, Jacintha O'Sullivan, Diarmuid O'Donoghue, John Hyland, Diarmuid O'Shea, Kieran Sheahan, Edel McDermott, Anne White, Blathnaid Nolan and 5 others

Experts in our system

1
Glen A Doherty
University College Dublin
Total Publications: 57
 
2
Hugh E Mulcahy
University College Dublin
Total Publications: 43
 
3
Jacintha O'Sullivan
Trinity College Dublin
Total Publications: 74
 
4
Diarmuid O'Donoghue
University College Dublin
Total Publications: 42
 
5
John Hyland
Dublin Business School
Total Publications: 47
 
6
Kieran Sheahan
University College Dublin
Total Publications: 40
 
7
Edel McDermott
University College Dublin
 
8
Blathnaid Nolan
Trinity College Dublin
Total Publications: 8