Type

Journal Article

Authors

Diarmuid O'Donoghue
Hugh Mulcahy
Kieran Sheahan
Glen Doherty
Denise Keegan
Grainne Holleran
Alan Coss
Aoibhlinn O'Toole

Subjects

Medicine & Nursing

Topics
treatment outcome female etiology colitis microscopic abdominal pain drug therapy complications fecal incontinence weight loss remission spontaneous diarrhea retrospective studies male therapeutic use budesonide pathology aged anti inflammatory agents humans middle aged

Microscopic colitis: clinical characteristics, treatment and outcomes in an Irish population. (2014)

Abstract Many aspects of microscopic colitis remain poorly understood. Our aim was to report a single centre experience with this condition. Two hundred and twenty-two patients (52 male, 170 female; median age 64 years; range 32-90) diagnosed between 1993 and 2010 were studied. Medical notes were reviewed, and data on age, gender, clinical features, history of autoimmune diseases, medication use, cigarette smoking, histology and outcome were collected. There were 99 cases of lymphocytic and 123 of collagenous colitis. Diarrhoea was almost invariably present (98 %) while abdominal pain (24 %), weight loss (10 %), faecal incontinence (8 %) and blood PR (5 %) were also described. Twenty-eight percent had concomitant autoimmune diseases, most commonly coeliac disease. Patients were taking a variety of medications at diagnosis thought to be associated with microscopic colitis including NSAIDs (22 %), aspirin (19 %), statins (15 %), proton pump inhibitors (19 %) and SSRIs (10 %) at diagnosis. Prior to the widespread use of budesonide in our institution, 33 % of patients required two or more medications during therapy compared to 15 % following the introduction of budesonide (p = 0.001). Thirty-eight percent of patients achieved spontaneous remission with either no treatment or simple anti-diarrhoeals. Using a multivariate model, the only factor associated with spontaneous remission was male gender (RR 1.9; 95 % CI 1.0-3.6; p = 0.04). Two patients had refractory microscopic colitis; one required a colectomy while a more recent case has responded to anti-TNF╬▒ therapy. Microscopic colitis is predominantly a benign and self-limiting disorder. The introduction of budesonide has revolutionised treatment of this lesser studied inflammatory bowel disease.
Collections Ireland -> University College Dublin -> PubMed

Full list of authors on original publication

Diarmuid O'Donoghue, Hugh Mulcahy, Kieran Sheahan, Glen Doherty, Denise Keegan, Grainne Holleran, Alan Coss, Aoibhlinn O'Toole

Experts in our system

1
Diarmuid O'Donoghue
University College Dublin
Total Publications: 42
 
2
Hugh E Mulcahy
University College Dublin
Total Publications: 43
 
3
Kieran Sheahan
University College Dublin
Total Publications: 40
 
4
Glen A Doherty
University College Dublin
Total Publications: 57
 
5
Denise Keegan
University College Dublin
Total Publications: 22