Type

Journal Article

Authors

Hugh Mulcahy
Diarmuid O'Donoghue
Glen Doherty
Kathryn Byrne
Denise Keegan
Paul Walsh
Aoibhlinn O'Toole

Subjects

Medicine & Nursing

Topics
adult young adult mortality risk factors ireland aged child preschool humans middle aged child cholangitis sclerosing female linear models inflammatory bowel diseases complications multivariate analysis epidemiology male follow up studies

Mortality in inflammatory bowel disease patients under 65 years of age. (2014)

Abstract To assess mortality in inflammatory bowel disease (IBD) patients under 65 years of age and to identify the factors related to death in this age group. METHODS. We studied 2570 IBD patients who were diagnosed as having disease before 65 years of age and attended a single tertiary referral center area between 1983 and 2012. Follow-up was censored at 65 years. The causes of death were determined from death certificates obtained from the Irish registry office of births, marriages and deaths. Observed all-cause survival was compared with expected survival of persons of the same age and sex in the general population. Expected survival was obtained from national life tables produced by the central statistics office. Survival estimates were calculated for disease type, disease site, gender, the presence of primary sclerosing cholangitis (PSC), immunomodulator use, biologic therapy use, presence of fistulating disease and prior surgery. Fifty-two deaths were reported in the population younger than 65 years, of which 41 were IBD related. We found little difference in survival in the first 25 years of follow-up, but relative survival decreased in both the Crohn's disease (CD) and ulcerative colitis (UC) cohort thereafter, so that 30-year mortality was excessive in both groups. An adjusted multivariate regression analysis of patients with CD identified PSC as the only predictor of premature mortality (p = 0.003). PSC was also identified as the only independent predictor of mortality in UC patients (p = 0.03). The presence of PSC poses the greatest risk for mortality in both UC and CD.
Collections Ireland -> University College Dublin -> PubMed

Full list of authors on original publication

Hugh Mulcahy, Diarmuid O'Donoghue, Glen Doherty, Kathryn Byrne, Denise Keegan, Paul Walsh, Aoibhlinn O'Toole

Experts in our system

1
Hugh E Mulcahy
University College Dublin
Total Publications: 43
 
2
Diarmuid O'Donoghue
University College Dublin
Total Publications: 42
 
3
Glen A Doherty
University College Dublin
Total Publications: 57
 
4
Kathryn Byrne
University College Dublin
Total Publications: 16
 
5
Denise Keegan
University College Dublin
Total Publications: 22