Type

Journal Article

Authors

P Ronan O'Connell
J Calvin Coffey
Desmond C. Winter
Aonghus Lavelle
Liam A Devane
Helen Earley
Aine Balfe
Gráinne Lennon

Subjects

Microbiology

Topics
disease bacteria immune system colon physical influences gel this review

Influences of the colonic microbiome on the mucous gel layer in ulcerative colitis. (2014)

Abstract The colonic mucus gel layer (MGL) is a critical component of the innate immune system acting as a physical barrier to microbes, luminal insults, and toxins. Mucins are the major component of the MGL. Selected microbes have the potential to interact with, bind to, and metabolize mucins. The tolerance of the host to the presence of these microbes is critical to maintaining MGL homeostasis. In disease states such as ulcerative colitis (UC), both the mucosa associated microbes and the constituent MGL mucins have been shown to be altered. Evidence is accumulating that implicates the potential for mucin degrading bacteria to negatively impact the MGL and its stasis. These effects appear more pronounced in UC.   This review is focused on the host-microbiome interactions within the setting of the MGL. Special focus is given to the mucolytic potential of microbes and their interactions in the setting of the colitic colon.
Collections Ireland -> University College Dublin -> PubMed

Full list of authors on original publication

P Ronan O'Connell, J Calvin Coffey, Desmond C. Winter, Aonghus Lavelle, Liam A Devane, Helen Earley, Aine Balfe, Gráinne Lennon

Experts in our system

1
P R O'Connell
University College Dublin
Total Publications: 75
 
2
J Calvin Coffey
University of Limerick
Total Publications: 72
 
3
Desmond C. Winter
University College Dublin
Total Publications: 53
 
4
Aonghus Lavelle
University College Cork
Total Publications: 7
 
5
Helen Earley
University of Limerick
 
6
Aine Balfe
University of Limerick
 
7
Grainne Lennon
University of Limerick