Type

Journal Article

Authors

Pauline M Rudd
Mohankumar Muniyappa
Louise Unwin
Simone Albrecht

Subjects

Microbiology

Topics
drug therapy humans metabolism blood proteins diagnosis arthritis rheumatoid glycosylation blood biological markers glycoproteins

Glycosylation as a marker for inflammatory arthritis. (2014)

Abstract Changes in serum protein glycosylation play an important role in inflammatory arthritis. Altered galactosylation of immunoglobulin G (IgG) in rheumatoid arthritis attracts special attention due to the devastating nature of the disease. Studying glycosylation changes of serum proteins has been recognized as a potential strategy to provide added value regarding diagnostics, aetiopathology and therapy of inflammatory arthritic diseases. Key questions, which are approached in these fields of research, are whether or not glycosylation can be used as a complementary pre-clinical and clinical marker for disease differentiation, diagnosis, the prediction of disease course and severity as well as for the evaluation of disease therapies. These studies mainly focus on TNF antagonists, which present a new and promising way of treating inflammatory arthritis. The recent availability of new high-throughput glycoanalytical tools enables a more profound and efficient investigation in large patient cohorts and helps to gain new insights in the complex mechanism of the underlying disease pathways.
Collections Ireland -> University College Dublin -> PubMed

Full list of authors on original publication

Pauline M Rudd, Mohankumar Muniyappa, Louise Unwin, Simone Albrecht

Experts in our system

1
Pauline M Rudd
University College Dublin
Total Publications: 45