Type

Journal Article

Authors

José López-Miranda
Helen Roche
Jose M Ordovas
Antonio Camargo
Ezequiel Herruzo-Gomez
Ulf Risérus
Aldona Dembinska-Kieć
Ellen E Blaak
Catherine Defoort
Christian A Drevon
and 6 others

Subjects

Veterinary

Topics
single nucleotide polymorphisms carbohydrate metabolism c peptide glucose tolerance test energy metabolism insulin resistance cardiovascular risk metabolic syndrome

Top Single Nucleotide Polymorphisms Affecting Carbohydrate Metabolism in Metabolic Syndrome: From the LIPGENE Study. (2013)

Abstract Rationale: Metabolic syndrome (MetS) is a high-prevalence condition characterized by altered energy metabolism, insulin resistance, and elevated cardiovascular risk. Objectives: Although many individual single nucleotide polymorphisms (SNPs) have been linked to certain MetS features, there are few studies analyzing the influence of SNPs on carbohydrate metabolism in MetS. Methods: A total of 904 SNPs (tag SNPs and functional SNPs) were tested for influence on 8 fasting and dynamic markers of carbohydrate metabolism, by performance of an intravenous glucose tolerance test in 450 participants in the LIPGENE study. Findings: From 382 initial gene-phenotype associations between SNPs and any phenotypic variables, 61 (16% of the preselected variables) remained significant after bootstrapping. Top SNPs affecting glucose metabolism variables were as follows: fasting glucose, rs26125 (PPARGC1B); fasting insulin, rs4759277 (LRP1); C-peptide, rs4759277 (LRP1); homeostasis assessment of insulin resistance, rs4759277 (LRP1); quantitative insulin sensitivity check index, rs184003 (AGER); sensitivity index, rs7301876 (ABCC9), acute insulin response to glucose, rs290481 (TCF7L2); and disposition index, rs12691 (CEBPA). Conclusions: We describe here the top SNPs linked to phenotypic features in carbohydrate metabolism among approximately 1000 candidate gene variations in fasting and postprandial samples of 450 patients with MetS from the LIPGENE study.
Collections Ireland -> University College Dublin -> PubMed

Full list of authors on original publication

José López-Miranda, Helen Roche, Jose M Ordovas, Antonio Camargo, Ezequiel Herruzo-Gomez, Ulf Risérus, Aldona Dembinska-Kieć, Ellen E Blaak, Catherine Defoort, Christian A Drevon and 6 others

Experts in our system

1
José López-Miranda
University College Dublin
Total Publications: 18
 
2
Helen M. Roche
University College Dublin
Total Publications: 105
 
3
Jose M Ordovas
University College Dublin
Total Publications: 8
 
4
Antonio Camargo
University College Dublin
 
5
Ulf Risérus
University College Dublin
 
6
Ellen E Blaak
University College Dublin
Total Publications: 11
 
7
Catherine Defoort
University College Dublin
Total Publications: 11
 
8
Christian A Drevon
University College Dublin
Total Publications: 39