Type

Journal Article

Authors

James Harris
David E. MacHugh
Karsten Hokamp
Cliona O'Farrelly
Clíona Ní Cheallaigh
Kate E Killick

Subjects

Biochemistry

Topics
toll like receptors dendritic cells receptor pathogens recognition receptors pattern recognition humans mycobacterium tuberculosis

Receptor-mediated recognition of mycobacterial pathogens. (2013)

Abstract Mycobacteria are a genus of bacteria that range from the non-pathogenic Mycobacterium smegmatis to Mycobacterium tuberculosis, the causative agent of tuberculosis in humans. Mycobacteria primarily infect host tissues through inhalation or ingestion. They are phagocytosed by host macrophages and dendritic cells. Here, conserved pathogen-associated molecular patterns (PAMPs) on the surface of mycobacteria are recognized by phagocytic pattern recognition receptors (PRRs). Several families of PRRs have been shown to non-opsonically recognize mycobacterial PAMPs, including membrane-bound C-type lectin receptors, membrane-bound and cytosolic Toll-like receptors and cytosolic NOD-like receptors. Recently, a possible role for intracellular cytosolic PRRs in the recognition of mycobacterial pathogens has been proposed. Here, we discuss currentideas on receptor-mediated recognition of mycobacterial pathogens by macrophages and dendritic cells.
Collections Ireland -> University College Dublin -> PubMed

Full list of authors on original publication

James Harris, David E. MacHugh, Karsten Hokamp, Cliona O'Farrelly, Clíona Ní Cheallaigh, Kate E Killick

Experts in our system

1
David E. MacHugh
University College Dublin
Total Publications: 82
 
2
Karsten Hokamp
Trinity College Dublin
Total Publications: 47
 
3
Cliona O'Farrelly
Trinity College Dublin
Total Publications: 147
 
4
Kate E Killick
University College Dublin
Total Publications: 14