Type

Journal Article

Authors

Michael J Gibney
Helen M. Roche
Lorraine Brennan
Eileen R Gibney
Marianne C Walsh
Ricardo Segurado
Ciara Morris
Colm O'Grada
Miriam F Ryan

Subjects

Veterinary

Topics
adults body composition health fatty acids postprandial single nucleotide polymorphisms variation biochemistry

Within-person variation in the postprandial lipemic response of healthy adults. (2013)

Abstract The response to dietary fat plays a key role in metabolic health. Although this can vary widely between individuals, variation within an individual and the associated contribution of phenotypic and genotypic factors to this variation are less defined. Objectives: The objectives were to quantify within-person variation in triacylglycerol response by means of a novel variation score (S(v)) and to explore the phenotypic and genotypic factors associated with this score. Two consecutive 5-h oral-lipid-tolerance tests (OLTTs) were conducted in 51 healthy adults aged 18-60 y with a BMI (in kg/m(2)) of 18.5 to 49.8. Detailed body composition, physical function, biochemistry, and genotype data were gathered. The postprandial triacylglycerol response profile did not differ (P = 0.64) across OLTTs for the group; nor did average concentrations of functional markers apolipoprotein C2 (P = 0.73) and apolipoprotein C3 (P = 0.74). S(v) was low in most (82%) of the adults and was significantly (P < 0.05) associated with age, fasting triacylglycerol, triacylglycerol AUC, and fasting nonessential fatty acids. Significant associations were also observed between S(v) and single nucleotide polymorphisms in 7 genes (APOA1, IL1α, IL1β, TLR4, TCF7L2, CCK1Rec, and STAT3) after correction for phenotypic differences. This work showed that the within-person variability in postprandial lipemic response is low in most healthy adults. It also showed that variability in this response is associated with a defined set of phenotypic and genotypic characteristics. This trial was registered at clinicaltrials.gov as NCT01172951.
Collections Ireland -> University College Dublin -> PubMed

Full list of authors on original publication

Michael J Gibney, Helen M. Roche, Lorraine Brennan, Eileen R Gibney, Marianne C Walsh, Ricardo Segurado, Ciara Morris, Colm O'Grada, Miriam F Ryan

Experts in our system

1
Michael J Gibney
University College Dublin
Total Publications: 102
 
2
Helen M. Roche
University College Dublin
Total Publications: 105
 
3
Lorraine Brennan
University College Dublin
Total Publications: 166
 
4
Eileen R Gibney
University College Dublin
Total Publications: 98
 
5
Marianne C Walsh
University College Dublin
Total Publications: 51
 
6
Ricardo Segurado
University College Dublin
Total Publications: 64
 
7
Miriam Ryan
University College Dublin
Total Publications: 34